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Last updated on September 14th, 2023
Insulin Mixtard 30/70 is a combination of two medications, a short-acting and an intermediate-acting type of insulin. It can be used to treat both types of diabetes (type 1 and 2) and improve blood glucose control. It can be given to both adults and children.
Mixtard 30/70 is generally recommended in combination with other diabetes medications. A physician or nurse can teach about the most appropriate way of injecting Mixtard suspension under the skin. This medication should be taken 15 minutes prior to a meal or within 20 minutes after going for a meal. Don’t stop its use unless a healthcare provider asks to.
Mixtard is only part of a treatment plan that must also involve a healthy diet, regular physical activity, and weight management as per the doctor’s recommendation. It is very important to regularly check blood glucose levels, check the results, and share them with a suitable physician. This is essential in order to work out the right dose of the medication for the patient.
What is Insulin Mixtard 30/70?
Mixtard is a suspension for injection consisting of an active ingredient, human insulin. It comes in vials, pre-filled pens (InnoLet or FlexPen), or cartridges (Penfill). Mixtard also is composed of both fast-acting (soluble) as well as long-acting (isophane) insulin:
- Mixtard 30: soluble insulin 30% and isophane insulin 70%;
- Insulin Mixtard 40: soluble insulin 40% and isophane insulin 60%;
- Mixtard 50: soluble insulin 50% and isophane insulin 50%.
Insulin Mixtard 30 70 injection offers a rapid in addition to a more prolonged duration effect, thereby assisting in maintaining the levels of blood glucose. This medication can be used with other anti-diabetic drugs in people with both type 1 and type 2 diabetes. Insulin should be injected at least 15 minutes before or within 20 minutes of initiating the meal. A person should never omit the meal or the dose of insulin.
Continue rotating the position of insulin administration. When a person is on Mixtard 30 70, a sugar or glucose candy must be kept handy as it can to reduce the levels of blood glucose (hypoglycemia) as its common ill effect.
How to Use Mixtard 30/70?
Mixtard is injected under the skin, in the areas of the thigh, deltoid area (shoulder), abdominal wall (front of the waistline), and gluteal area (buttocks). The injection site must be altered for each injection. Also, tests should be done regularly to check the patient’s blood sugar levels to find the lowest effective dose. As per the Vinmec International Hospital, the usual recommended dose is between 0.3 and 1.0 international units (IU) per kilogram of body weight per day. Also, the injection is given half an hour before a meal. It is generally given once or twice daily when there is a requirement for a fast primary effect in combination with a more long-lasting effect.
How Does Insulin Mixtard act?
Diabetes is a medical condition in which the body fails to form an adequate amount of insulin to control the blood sugar or when the body fails to utilize the insulin in an effective manner. Mixtard is a replacement insulin that acts similarly to the insulin produced by the pancreas.
The active component in Mixtard, human insulin, is formed by a method called recombinant technology, as stated by the National Institutes of Health. In this method, the production of insulin occurs by yeast cells into which a gene (DNA) has been introduced. This makes them capable of forming insulin. Mixtard is also composed of insulin in two forms: a soluble form, which acts rapidly (within half an hour of injection) and an ‘isophane’, which gets absorbed gradually throughout the day.
Due to this, Mixtard is a longer-acting insulin. Replacement insulin works similarly to naturally formed insulin and helps sugar get into the cells in the bloodstream. The signs and complications of diabetes can be lowered by regulating blood sugar levels.
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Uses of Insulin Mixtard 30/70
- The injection is used to treat diabetes mellitus (Type 1 & Type 2)
Benefits of Insulin Mixtard Suspension for Injection
As per the Better Health Channel, mixtard 30 70 is composed of an intermediate-acting and short-acting type of insulin. In combination, they make sure that fast and consistent glucose control occurs. This assists in controlling the blood glucose levels for a complete day. It can be given as an injection, and the doctor or nurse will train them on the right way to inject it.
Management of blood sugar levels is an indispensable part of managing diabetes. If a person can control the level, they will decrease the risk of getting severe diabetes complications, including eye damage, kidney damage, nerve issues, as well as loss of limbs. Using this medication often, together with proper diet and exercise, will help a person live a normal, healthy life.
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Side effects of Insulin Mixtard 30/70
Many ill effects do not need medical attention and vanish as the person’s body adjusts to the medication. Consult with one’s physician if they continue or are worried about them. The common side effects can be:
- Allergic reaction at the injection site
- Rash and edema
- Weight gain
- Lipodystrophy (skin thickening or pits at the site of injection)
- Irritation
Also, the most common Mixtard side effect is low blood glucose levels (hypoglycemia). In order to prevent this, it’s vital always to inject the correct dosage of the drug only, take regular meals, as well as monitor the levels of blood sugar frequently. Intake of too much alcohol might also bring about a fall in blood glucose levels. Other side effects may involve reactions at the injection site, such as inflammation or redness. Few individuals may also gain weight while using insulin. In addition, the patient might also observe a rash, oedema (inflammation), or irritation while using this medication.
How has Insulin Mixtard been studied?
As per a study conducted by the European Medicine Agency, this form of insulin has been studied in a total of 294 patients having type-1 diabetes. In this condition, the pancreas fails to form insulin, and in type-2 diabetes, the body is incapable of using this insulin effectively. Approximately 1/3rd of the patients had type-1 diabetes, and the remaining had type-2 diabetes. The study evaluated Mixtard 30 as a comparable combination but produced by using an insulin analogue (insulin aspart). Also, the research study assessed the level of a substance in the blood named glycosylated haemoglobin (HbA1c) post-12 weeks, which provides a signal of control over blood sugar levels.
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Is there any beneficial effect of Mixtard during the studies?
It was found that Mixtard led to a reduction in the HbA1c levels, signifying that blood sugar levels had been regulated to a comparable level to that seen with other insulin forms. Mixtard was found to be efficacious for both type-1 and type-2 diabetes.
Important safety information
- Avoid using Insulin Mixtard when a person has low blood sugar levels (hypoglycemia).
- Also, it is essential to inform the doctor if the person has had renal, liver, or heart issues before initiating the treatment.
- Pregnant or lactating females must also discuss with their doctor as the dose might require a dose modification.
- Do not self-administer this medicine.
- It is not safe to have alcohol with Mixtard 30 70 Suspension for Injection.
- A person’s ability to drive might be affected if their blood glucose is too low or too high. Avoid driving if these signs occur.
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Quick Tips
- Injection underneath the skin of the abdomen can bring about a rapid absorption of the medicament as compared to other injection sites, including the skin of the upper arms, buttocks, or thighs. Also, it is not recommended to massage the injection site post-injection.
- Take the medication 15 minutes prior to a meal or within 20 minutes after beginning with a meal.
- Change to another form of insulin must be performed only under strict medical supervision as it might need a modification in the dosage.
- Rotation of injection sites should be done in order to avoid the development of hard lumps at one site.
- Avoid sharing the insulin device with other individuals, even though the needle has been altered. Severe infections can be transferred or caught.
- Opened vials or cartridges must be kept at room temperature for up to 4 weeks, whereas unopened vials can be placed in the refrigerator at a temperature range of about 2°C to 8°C.
- Hypoglycemia (low levels of blood glucose) can occur when Mixtard is used along with other anti-diabetic drugs, alcohol, or missing or delaying a meal. A glucose source must always be carried along for instant relief.
- A risk management program must be developed to ensure that Mixtard is being used as safely as possible.
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Summary
Mixtard 30/70 suspension for injection begins to reduce a diabetic patient’s blood glucose level about 30 minutes after they inject. The effect persists for around 24 hours. As with all insulins, the duration of action with this medicine also differs according to the form of insulin, dose, blood flow, injection site, temperature, and level of physical activity. Mixtard 30/70 is a pre-mixed neutral insulin suspension available in the composition of 100 IU/mL.
The injectable contains a neutral insulin injection (30%) and an isophane insulin injection (70%). Other ingredients may include phenol, glycerol, sodium phosphate dihydrate, meta-cresol, protamine sulfate, zinc chloride, and water for injection. Sodium hydroxide and hydrochloric acid are also added which are basically for adjusting the pH of the injectable.
Patients with diabetes might not be capable of using the sugar owing to the inadequate production of insulin because of the body’s incapability of utilising the insulin, or both. This medication aids in using the sugar and regulating its levels in such patients. Patients are recommended to follow strict exercise as well as a diet regimen in combination with this drug to attain the best possible effects.
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FAQ’s (Frequently Asked Questions)
The use of insulin by lactating females is considered adequate. Breastfeeding females usually necessitate adjustments in insulin dosages.
Mixtard is considered safe for use by pregnant females, but it should be used only when essential as the potential benefits balance the risks.
The effect of this medication persists for an average duration of 24 hours.
No, it is not a habit-forming medicine.
Intake of alcohol is not suggested during treatment with Mixtard owing to the increased risk of both hypoglycemia (low blood sugar) as well as hyperglycemia (high blood sugar) based upon the quantity and incidence of alcohol intake. This might bring about serious side effects like drowsiness, enhanced thirst and hunger, intense weakness, and mood changes.
The effect of Mixtard suspension of injection can be observed within half an hour to one hour of administration of the dose.
Disclaimer
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